Pathways of coagulation activation in situ in rheumatoid synovial tissue
| Autor: | Christopher T. Dunwiddie, Elka M. Nutt, Jane A. Hunt, Sandra M. Rousseau, Vincent A. Memoli, Bohdan J. Kudryk, Forst E. Brown, Walter Kisiel, Leo R. Zacharski |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Immunology Inflammation Fibrinogen Fibrin Thromboplastin Pathology and Forensic Medicine Arthritis Rheumatoid Thrombin Fibrinolysis medicine Humans Immunology and Allergy Urokinase Factor XIII biology Chemistry Macrophages Synovial Membrane Factor V Blood Coagulation Disorders Factor VII Immunohistochemistry Plasminogen Inactivators medicine.anatomical_structure Factor X biology.protein medicine.symptom Synovial membrane Plasminogen activator medicine.drug |
| Zdroj: | Clinical Immunology and Immunopathology. 63:155-162 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(92)90008-c |
| Popis: | Immunohistochemical techniques were applied to rheumatoid synovium in order to detect components of coagulation and fibrinolysis pathways within these tissues. These techniques revealed an intact coagulation pathway and plasminogen activator inhibitor-2 associated with macrophagelike cells that were present throughout these tissues, especially in subsurface areas. Cell-associated thrombin generation appeared to account for conversion of abundant fibrinogen to fibrin. Occasional macrophage-like cells also stained for urokinase but tissue-type plasminogen activator and plasminogen activator inhibitor-1 were restricted to vascular endothelium. Intense synovial fibrin deposition (with the limited evidence for associated fibrinolysis) may contribute to local inflammation and explain certain clinical features of rheumatoid arthritis. These findings suggest novel treatment hypotheses for this disease. |
| Databáze: | OpenAIRE |
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