Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

Autor:	Thomas M. Haas, Nikolaus Jork, Christoph Nopper, Claudia Jessen-Trefzer, Nicole Steck, Verena B. Eisenbeis, Tobias Dürr, Paul Ebensperger, Henning J. Jessen
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Nucleotides 010405 organic chemistry Chemistry Hydrolysis Metals and Alloys Magic (programming) Stereoisomerism General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Phosphates 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cyclization Biocatalysis Endoribonucleases Materials Chemistry Ceramics and Composites Electrophoresis Polyacrylamide Gel Nucleotide
Zdroj:	Chemical Communications. 55:5339-5342
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c9cc01688k
Popis:	A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef123359e3907abc25d0e02e65d6c5f1 https://doi.org/10.1039/c9cc01688k Zobrazit plný text záznamu