Expression Analysis of Protein Inhibitor of Activated STAT in Inflammatory Demyelinating Polyradiculoneuropathy

Autor: Mohammad Taheri, Fwad Nicknafs, Soudeh Ghafouri-Fard, Arezou Sayad, Naghme Nazer, Bashdar Mahmud Hussen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
Male
PIAS
Immunology
CIDP
Guillain-Barre Syndrome
AIDP
stat
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Immune system
Expression analysis
Immunology and Allergy
Medicine
Humans
Protein inhibitor of activated STAT
Stat signaling
inflammatory demyelinating polyradiculoneuropathy
Gene
Original Research
Aged
protein inhibitor of activated STAT
business.industry
Disease Management
Polyradiculoneuropathy
Bayes Theorem
RC581-607
Middle Aged
medicine.disease
Prognosis
Protein Inhibitors of Activated STAT
030104 developmental biology
Gene Expression Regulation
Polyradiculoneuropathy
Chronic Inflammatory Demyelinating
ROC Curve
Multigene Family
Female
Disease Susceptibility
Immunologic diseases. Allergy
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
ISSN: 1664-3224
Popis: Protein inhibitors of activated STAT (PIAS) are involved in the regulation of the JAK/STAT signaling pathway and have interactions with NF-κB, p73 and p53. These proteins regulate immune responses; therefore dysregulation in their expression leads to several immune-mediated disorders. In the present study, we examined expression of PIAS1-4 in peripheral blood of patients with acute/chronic inflammatory demyelinating polyradiculoneuropathy (AIDP/CIDP) compared with healthy subjects. We demonstrated down-regulation of all PIAS genes in both AIDP and CIDP cases compared with controls. Similarly, comparisons in gender-based groups revealed down-regulation of these gene0s in patients of each gender compared with gender-matched controls. There was no significant difference in expression of PIAS genes between AIDP and CIDP cases. Based on the area under the receiver operating characteristic curves, PIAS1-4 genes could distinguish between inflammatory demyelinating polyradiculoneuropathy and healthy status with accuracy values of 0.87, 0.87, 0.79 and 0.80, respectively. In differentiation between AIDP cases and healthy controls, these values were 0.92, 0.92, 0.83 and 0.86, respectively. Finally, PIAS1-4 genes could discriminate CIDP from healthy status with accuracy values of 0.82, 0.83, 0.75 and 0.75, respectively. The current study underscores the role of PIAS genes in the pathogenesis of inflammatory demyelinating polyradiculoneuropathy and their potential usage as biomarkers.
Databáze: OpenAIRE
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