A Case of Sepsis Caused by Enterobacter cloacae Producing Both type SHV-12 and type CTX-M-14 ESBLs in a Post Bone-Marrow Transplantation Patient
| Autor: | Naohiro Shibata, Tomokazu Suzuki, Yoshichika Arakawa, Misao Homma |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Bone marrow transplantation medicine.drug_class Cephalosporin Meropenem beta-Lactamases Microbiology Sepsis Postoperative Complications Enterobacter cloacae polycyclic compounds medicine Humans Blood culture Bone Marrow Transplantation biology medicine.diagnostic_test business.industry General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification medicine.disease Transplantation bacteria Female business Bacteria medicine.drug |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 81:745-750 |
| ISSN: | 1884-569X 0387-5911 |
| Popis: | Third-generation cephalosporin-resistant Enterobacter cloacae was isolated from the blood culture of a 31-year-old woman after bone-marrow transplantation. Since this strain was resistant to third-generation cephalosporins, the production of extended-spectrum beta-lactamases (ESBLs) was suspected. PCR and a sequence analysis confirmed two ESBL genes, bla(SHV-12) and bla(CTX-M-14). No bacteria were detected after meropenem was administered, and symptoms abated. This is, to our knowledge, the first report in Japan of E. cloacae clinical isolates simultaneously producing both SHV-12 and CTX-M-14 ESBL. In cases where chromosomal AmpC over-production of E. cloacae concomitantly produces ESBL, caution should be exercised due to the potential development of resistance against extended-spectrum beta-lactam agents. |
| Databáze: | OpenAIRE |
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