A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila
| Autor: | Madelen M. Díaz, Meghana Holla, Michael Rosbash, Fang Guo |
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| Rok vydání: | 2018 |
| Předmět: |
Brain Chemistry
Male 0301 basic medicine Dorsum General Neuroscience Sleep wake Brain Biology Optogenetics Sleep in non-human animals Circadian Rhythm Arousal 03 medical and health sciences Drosophila melanogaster 030104 developmental biology Calcium oscillation Animals Circadian rhythm Nerve Net Wakefulness Sleep Neuroscience Locomotion |
| Zdroj: | Neuron. 100:624-635.e4 |
| ISSN: | 0896-6273 |
| Popis: | The Drosophila core circadian circuit contains distinct groups of interacting neurons that give rise to diurnal sleep-wake patterns. Previous work showed that a subset of dorsal neurons 1 (DN1s) are sleep-promoting through their inhibition of activity-promoting circadian pacemakers. Here we show that these anterior-projecting DNs (APDNs) also "exit" the circadian circuitry and communicate with the homeostatic sleep center in higher brain regions to regulate sleep and sleep-wake arousal. These APDNs connect to a small, discrete subset of tubercular-bulbar neurons, which are connected in turn to specific sleep-centric ellipsoid body (EB)-ring neurons of the central complex. Remarkably, activation of the APDNs produces sleep-like oscillations in the EB and affects arousal. The data indicate that this APDN-TuBusup-EB circuit temporally regulates sleep-wake arousal in addition to the previously defined role of the TuBu-EB circuit in vision, navigation, and attention. |
| Databáze: | OpenAIRE |
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