Cerebral injury during cardiopulmonary bypass: Emboli impair memory
| Autor: | T.L. Hooper, S.J. Fearn, K Wesnes, E.B. Faragher, Charles McCollum, R. Pole |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Coronary Disease Cerebral oxygen saturation law.invention Reference Values Risk Factors law Interquartile range medicine.artery Preoperative Care Cardiopulmonary bypass medicine Humans Postoperative Period Embolization Coronary Artery Bypass Cerebral perfusion pressure Aged Probability Aged 80 and over Neurologic Examination Memory Disorders Cardiopulmonary Bypass business.industry Incidence Ultrasonography Doppler Middle Aged Cardiac surgery Transcranial Doppler Treatment Outcome Intracranial Embolism Anesthesia Middle cerebral artery Female Surgery Cognition Disorders Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 121:1150-1160 |
| ISSN: | 0022-5223 |
| DOI: | 10.1067/mtc.2001.114099 |
| Popis: | Objectives: Cognitive deficits occur in up to 80% of patients after cardiac surgery. We investigated the influence of cerebral perfusion and embolization during cardiopulmonary bypass on cognitive function and recovery. Methods: Cerebrovascular reactivity was measured in 70 patients before coronary operations in which nonpulsatile bypass was used. Throughout the operations, middle cerebral artery flow velocity and embolization were recorded by transcranial Doppler and regional oxygen saturation was recorded by near-infrared spectroscopy. Cognitive function was measured by a computerized battery of tests before the operation and 1 week, 2 months, and 6 months after surgery. Elderly patients undergoing urologic surgery served as controls. Results: Cerebrovascular reactivity was impaired preoperatively in 49 patients. Median (interquartile range) regional cerebral oxygen saturation fell during bypass by 10% (6%-15%), indicating increased oxygen extraction, whereas mean middle cerebral flow velocity increased significantly by a median of 6 cm/s (both P |
| Databáze: | OpenAIRE |
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