Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma
| Autor: | Bas P. L. Wijnhoven, Hetty A. G. M. van der Korput, Carel J. M. van Noesel, Anna M. J. van Nistelrooij, Hugo W. Tilanus, Albert Hofman, Mark I. van Berge Henegouwen, Winand N.M. Dinjens, Ronald van Marion, Manon C.W. Spaander, Katharina Biermann, André G. Uitterlinden, Linda Broer, J. Jan B. van Lanschot |
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| Přispěvatelé: | Surgery, Pathology, Cardiothoracic Surgery, Epidemiology, Gastroenterology & Hepatology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty esophageal adenocarcinoma Health Toxicology and Mutagenesis Population Genome-wide association study Single-nucleotide polymorphism Bioinformatics lcsh:RC254-282 03 medical and health sciences Rotterdam Study Barrett's esophagus single nucleotide polymorphisms 0302 clinical medicine Internal medicine Medicine education Prospective cohort study Allele frequency 030304 developmental biology 0303 health sciences education.field_of_study business.industry Odds ratio lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health Minor allele frequency 030220 oncology & carcinogenesis Original Article business Barrett′s esophagus |
| Zdroj: | Journal of carcinogenesis, 14. Medknow Publications and Media Pvt. Ltd Journal of Carcinogenesis, 14:5. Wolters Kluwer Medknow Journal of Carcinogenesis, Vol 14, Iss 1, Pp 5-5 (2015) Journal of Carcinogenesis |
| ISSN: | 1477-3163 0974-6773 |
| Popis: | Objective: Recently, single nucleotide polymorphisms (SNPs) associated with esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) were identified; rs10419226 (CRTC10), rs11789015 (BARX1), rs2687201 (FOXP10), rs2178146 (FOXF1), rs3111601 (FOXF10), and rs9936833 (FOXF1). These findings indicate that genetic susceptibility could play a role in the initiation of EAC in BE patients. The aim of this study was to validate the association between these previously identified SNPs and the risk of EAC in an independent and large case-control study. Design: Six SNPs found to be associated with EAC and BE were genotyped by a multiplex SNaPshot analysis in 1071 EAC patients diagnosed and treated in the Netherlands. Allele frequencies were compared to a control group derived from the Rotterdam Study, a population-based prospective cohort study (n = 6206). Logistic regression analysis and meta-analysis were performed to calculate odds ratios (OR). Results: Rs10419226 (CRTC1) showed a significantly increased EAC risk for the minor allele (OR = 1.17, P = 0.001), and rs11789015 (BARX1) showed a significantly decreased risk for the minor allele (OR = 0.85, P = 0.004) in the logistic regression analysis. The meta-analysis of the original GWAS and the current study revealed an improved level of significance for rs10419226 (CRTC1) (OR = 1.18, P = 6.66 × 10-10 ) and rs11789015 (BARX1) (OR = 0.83, P = 1.13 × 10-8 ). Conclusions: This independent and large Dutch case-control study confirms the association of rs10419226 (CRTC1) and rs11789015 (BARX1) with the risk of EAC. These findings suggest a contribution of the patient genetic make-up to the development of EAC and might contribute to gain more insight in the etiology of this cancer. |
| Databáze: | OpenAIRE |
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