Broad spectrum in vitro microbicidal activity of benzoyl peroxide against microorganisms related to cutaneous diseases
| Autor: | Masataka Oda, Shoji Kanayama, Naoki Hayashi, Kazuaki Okamoto, Tatsumi Matsumoto, Shiori Fujiwara, Koki Fujikawa, Fumiaki Ikeda, Sachi Mori, Naoki Nozawa |
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| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus
Concise Communications Cutibacterium Microbial Sensitivity Tests Dermatology Benzoyl peroxide medicine.disease_cause Bacterial cell structure Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Staphylococcus epidermidis medicine Propionibacterium acnes Candida albicans Malassezia Benzoyl Peroxide integumentary system biology Chemistry organic chemicals Concise Communication General Medicine biology.organism_classification Staphylococcus aureus 030220 oncology & carcinogenesis microbicidal Bacteria medicine.drug |
| Zdroj: | The Journal of Dermatology |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/1346-8138.15739 |
| Popis: | The in vitro microbicidal activity of benzoyl peroxide against Cutibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Malassezia furfur, Malassezia restricta, and Malassezia globosa was investigated. These strains were incubated for 1 h in the presence of 0.25, 0.5, 1, or 2 mmol/L benzoyl peroxide in phosphate buffered saline supplemented with 0.1% glycerol and 2% Tween 80. After exposure to benzoyl peroxide, counts of viable Gram‐positive bacteria and fungi were markedly decreased, whereas counts of Gram‐negative bacteria were unchanged. Transmission electron microscopy images showed a decrease in electron density and the destruction of C. acnes and M. restricta cell walls after exposure to 2 mmol/L benzoyl peroxide. In conclusion, this study showed that benzoyl peroxide has a potent and rapid microbicidal activity against Gram‐positive bacteria and fungi that are associated with various cutaneous diseases. This suggests that the direct destruction of bacterial cell walls by benzoyl peroxide is an essential mechanism of its rapid and potent microbicidal activity against microorganisms. |
| Databáze: | OpenAIRE |
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