Genotoxicity in Alzheimers Disease: Role of Amyloid
| Autor: | Annamalai Prakasam, Chitra Venugopal, Anitha Suram, Kumar Sambamurti |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Amyloid
Tau protein Apoptosis Inflammation Proteomics medicine.disease_cause Alzheimer Disease medicine Animals Humans Senile plaques Amyloid beta-Peptides biology Neurodegeneration Brain medicine.disease Genes cdc Oxidative Stress Neurology Biochemistry Mutation biology.protein Neurology (clinical) Tumor Suppressor Protein p53 Alzheimer's disease medicine.symptom Oxidative stress DNA Damage Signal Transduction |
| Zdroj: | Current Alzheimer Research. 3:365-375 |
| ISSN: | 1567-2050 |
| Popis: | Alzheimer's disease (AD) is a complex neurodegenerative disorder pathologically identified by the presence of extracellular senile plaques (SP) with a proteinaceous core composed of aggregates of the amyloid peptide (Abeta) and intracellular aggregates of the microtubule-associated protein tau (tau) as neurofibrillary tangles (NFTs). These hallmarks consist of abnormally folded proteinaceous components that are believed to be neurotoxic in AD. The mechanisms of toxicity remain unclear although oxidative stress and inflammation are implicated as mediators of the toxicity and these lesions, in turn, are known to damage cellular components including proteins, lipids in the membrane and DNA. However effects on genotoxicity and its role in AD are less clear. The present review discusses various influences, in particular of amyloid, on the genetic material and their possible role in the neurodegeneration in AD. Further, the amalgamation of genomics and proteomics in understanding AD and therapeutic development is suggested. |
| Databáze: | OpenAIRE |
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