| Autor: |
Yuxin Che, Shihan Fu, Huan Wang, Jinguo Suo, Chunyan Chen, Dan Pu, Can Li, Yang Yang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS Infectious Diseases. 8:2494-2504 |
| ISSN: |
2373-8227 |
| DOI: |
10.1021/acsinfecdis.2c00305 |
| Popis: |
Human papillomavirus (HPV) is the most common sexually transmitted pathogen worldwide and the major risk factor for cervical cancer. According to our previous study, antitumor immune responses induced by a therapeutic vaccine based on HPV E7 peptide are highly variable among individuals. Many studies have demonstrated that the discrepancy in the gut microbiota is an important factor in the development and regulation of the immune system. Therefore, we performed a systematic comparative analysis of gut microbiota in two groups of mice with significant differences in antitumor effects induced by the vaccine, as well as the correlation between immune cells and gut microbiota. We divided the mice into group A, in which the tumor continued growing, and group B, in which the tumor volume was significantly reduced. In group B mice, the vaccination induced a stronger antitumor activity with significantly enhanced IFN-γ-producing CD4+ and CD8+ T lymphocytes, as well as decreased immunosuppressive cells. A detailed gut microbiota analysis revealed a positive Spearman correlation between the percentage of CD8+ T cells and the relative abundance of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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