Reduced virulence of a pseudorabies virus isolate from wild boar origin in domestic pigs correlates with hampered visceral spread and age-dependent reduced neuroinvasive capacity

Autor: Nick De Regge, Ann Brigitte Cay, Valerie Redant, Herman W. Favoreel, Sara Verpoest
Rok vydání: 2017
Předmět:
0301 basic medicine
Swine
animal diseases
viruses
INVASION
Pseudorabies
Age dependent
Antibodies
Viral
Virus Replication
Nervous System
neuroinvasion
CYTOPLASMIC TAIL
Pathogenesis
Viral Envelope Proteins
INFECTION
NERVE
SWINE
Swine Diseases
GE
Virulence
biology
pathogenesis
Age Factors
virus diseases
Herpesvirus 1
Suid
Infectious Diseases
olfactory bulb
BASEMENT-MEMBRANE
Cytokines
wild boar
Research Paper
Microbiology (medical)
STRAIN
Immunology
Herpesvirus suis
Microbiology
Virus
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Wild boar
biology.animal
Animals
AUJESZKYS-DISEASE VIRUS
lcsh:RC109-216
Veterinary Sciences
RNA
Messenger
urogenital system
Biology and Life Sciences
biochemical phenomena
metabolism
and nutrition
pseudorabies virus
biology.organism_classification
Virology
RESPIRATORY MUCOSA
virulence
Viral Tropism
030104 developmental biology
DNA
Viral
Parasitology
Zdroj: Virulence
Virulence, Vol 9, Iss 1, Pp 149-162 (2018)
VIRULENCE
ISSN: 2150-5608
2150-5594
DOI: 10.1080/21505594.2017.1368941
Popis: Morbidity and mortality associated with pseudorabies virus (PRV) infection are dependent on the age of the pig and the virulence of the strain. PRV strains circulating in wild boar are considered to be low virulent, but no mechanistic explanation for their reduced virulence is available. Here infection of 2- and 15-week-old domestic pigs with the PRV wild boar strain BEL24043 did not induce clinical symptoms in 15-week-old pigs, but resulted in important neurological and respiratory disease in 2-week-old piglets. A detailed study of the (neuro) pathogenesis and associated cytokine mRNA expression showed that the reduced virulence of the wild boar strain, compared to what was previously reported for the virulent domestic NIA3 strain, is due to a severely hampered spread to visceral organs in pigs of both age categories and to an efficient suppression of viral replication at primary replication sites of 15-week-old pigs and to a lesser extent in those of 2-week-old piglets. The age-dependent difference in induced symptoms seems to be due to an immature development state of the immune and/or nervous system in 2-week-old pigs. An extensive viral replication associated with a robust expression of cytokine-related mRNA was found in the olfactory bulb of 2-week-old piglets, correlating with observed neurological disease. Neuroinvasion also occurred via the trigeminal route in 2-week-old pigs, but viral replication was efficiently suppressed in the trigeminal ganglion in the presence of a moderate induction of cytokine-related mRNA. Viral replication in the peripheral and central nervous system of 15-week-old pigs was limited and efficiently suppressed.
Databáze: OpenAIRE
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