Cytotoxicity, mutagenicity and acute oral toxicity of aqueous Ocotea minarum leaf extracts
| Autor: | Silvia Aparecida Oesterreich, Renata Pires de Araújo, Melyssa Negri, Pamella Fukuda de Castilho, Adriana Araújo de Almeida-Apolonio, Claudia Andrea Lima Cardoso, Fernanda de Oliveira Galvão, Fabiana Gomes da Silva Dantas, Kelly Mari Pires de Oliveira |
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| Rok vydání: | 2020 |
| Předmět: |
integumentary system
Traditional medicine 010405 organic chemistry Chemistry Organic Chemistry food and beverages Plant Science medicine.disease_cause 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry medicine Oral toxicity Cytotoxicity neoplasms Ocotea minarum Oxidative stress |
| DOI: | 10.6084/m9.figshare.13347331.v2 |
| Popis: | Ocotea minarum (Nees & Mart.) Mez., a native species of Brazil, is used in the treatment of infections and oxidative stress; however, there is no scientific evidence of its toxicological characteristics. We assessed the cytotoxicity, mutagenic activity, and acute oral toxicity of the aqueous extract isolated from O. minarum leaves. The cytotoxicity of this extract was evaluated in tumour and non-tumour cell lines, while the Ames test with a Salmonella Typhimurium was used to determine the mutagenic activity. Wistar rats received a single 2 g/kg dose as part of an LD50 toxicity assessment. Our results showed that the aqueous extract of O. minarum leaves did not present cytotoxic and mutagenic properties and was not toxic, with an LD50 greater than 2 g/kg. Therefore, the O. minarum extracts are pharmacologically safe and can continue to be investigated for the development of new drugs and herbal medicines. |
| Databáze: | OpenAIRE |
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