Peripheral inflammation and neuroprotection: Systemic pretreatment with complete Freund's adjuvant reduces 6-hydroxydopamine toxicity in a rodent model of Parkinson's disease
| Autor: | Giovanna Levandis, Giuseppe Nappi, M.T. Armentero, Fabio Blandini, Eleonora Bazzini |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_treatment Freund's Adjuvant Substantia nigra Motor Activity Biology Pharmacology Neuroprotection Striatum lcsh:RC321-571 Rats Sprague-Dawley Astroglia Random Allocation chemistry.chemical_compound Adjuvants Immunologic Parkinsonian Disorders Neurotrophic factors medicine Glial cell line-derived neurotrophic factor Animals Neurodegeneration Oxidopamine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Analysis of Variance Hydroxydopamine Substantia nigra pars compacta Rats Neostriatum Substantia Nigra Disease Models Animal Neuroprotective Agents Cytokine nervous system Neurology chemistry Freund's adjuvant Nerve Degeneration Immunology biology.protein Microglia Tyrosine hydroxylase Neuroglia |
| Zdroj: | Neurobiology of Disease, Vol 24, Iss 3, Pp 492-505 (2006) |
| ISSN: | 0969-9961 |
| DOI: | 10.1016/j.nbd.2006.08.016 |
| Popis: | Complete Freund's adjuvant (CFA), a pro-inflammatory agent, was inoculated, subcutaneously, to Sprague-Dawley rats prior to the intrastriatal injection of 6-hydroxydopamine (6-OHDA). Animals were sacrificed 7 and 28 days following 6-OHDA injection; neuronal damage, glial activation and cytokine levels, within the nigrostriatal system, were then investigated. Nigrostriatal degeneration induced by 6-OHDA was accompanied by early microglial and astroglial activation, which preceded the onset of dopaminergic cell loss, in the SNc, without significant changes in cytokine levels. CFA pretreatment markedly reduced the SNc neuronal loss and associated microglial activation, as well as the rotational response to apomorphine. These changes were associated with moderate, transient increases in the nigrostriatal levels of glial-cell-derived neurotrophic factor (GDNF) and pro-inflammatory cytokines, including interleukin (IL)-1alpha, IL-1beta and IL-6. Our results show that prior delivery of a peripheral, pro-inflammatory stimulus induces neuroprotection, in a rodent model of Parkinson's disease, possibly through the modulation of cytokine production at the nigrostriatal level. |
| Databáze: | OpenAIRE |
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