Comparative Genomics of the Genus Porphyromonas Identifies Adaptations for Heme Synthesis within the Prevalent Canine Oral Species Porphyromonas cangingivalis
| Autor: | Oliver Deusch, Corrin Wallis, Ian J. Davis, Ciaran O’Flynn, Jonathan A. Eisen, Stephen Harris, Aaron E. Darling |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Physiological
periodontal disease canine Porphyromonas comparative genomics Heme Bioinformatics medicine.disease_cause Genome plaque chemistry.chemical_compound Dogs Siroheme Phylogenetics Genetics medicine Animals Humans Dental/Oral and Craniofacial Disease Adaptation Porphyromonas gingivalis Ecology Evolution Behavior and Systematics Phylogeny Nutrition Comparative genomics Evolutionary Biology Mouth biology Porphyromonas cangingivalis Bacterial biology.organism_classification Adaptation Physiological chemistry Host-Pathogen Interactions Biochemistry and Cell Biology Digestive Diseases Genome Bacterial Biotechnology Developmental Biology Research Article |
| Zdroj: | Genome Biology and Evolution Genome biology and evolution, vol 7, iss 12 O'Flynn, C; Deusch, O; Darling, AE; Eisen, JA; Wallis, C; Davis, IJ; et al.(2015). Comparative genomics of the genus porphyromonas identifies adaptations for heme synthesis within the prevalent canine oral species porphyromonas cangingivalis. Genome Biology and Evolution, 7(12), 3397-3413. doi: 10.1093/gbe/evv220. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4zx1h3rp |
| ISSN: | 1759-6653 |
| DOI: | 10.1093/gbe/evv220. |
| Popis: | © 2015 The Author(s). Porphyromonads play an important role inhuman periodontal disease and recently have been shownto be highly prevalent in canine mouths. Porphyromonas cangingivalis is the most prevalent canine oral bacterial species in both plaque from healthy gingiva and plaque from dogs with early periodontitis. The ability of P. cangingivalis to flourish in the different environmental conditions characterized by these two states suggests a degree of metabolic flexibility. To characterize the genes responsible for this, the genomes of 32 isolates (including 18 newly sequenced and assembled) from18Porphyromonad species fromdogs, humans, and other mammals were compared. Phylogenetic trees inferred using core genes largely matched previous findings; however, comparative genomic analysis identified several genes and pathways relating to heme synthesis that were present in P. cangingivalis but not in other Porphyromonads. Porphyromonas cangingivalis has a complete protoporphyrin IX synthesis pathway potentially allowing it to synthesize its own heme unlike pathogenic Porphyromonads such as Porphyromonas gingivalis that acquire heme predominantly from blood. Other pathway differences such as the ability to synthesize siroheme and vitamin B12 point to enhanced metabolic flexibility for P. cangingivalis, which may underlie its prevalence in the canine oral cavity. |
| Databáze: | OpenAIRE |
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