A Systematic Approach to Assess the Burden of Drug Interactions in Adult Kidney Transplant Patients
| Autor: | Jeronimo Espinosa, Guillermo Alberto Keller, Maria C. Soler Riera, Claudio Gonzalez, Guillermo Di Girolamo, Paulino Alvarez, Cristian Lopez Saubidet, Fernando Bril, Gervasio S. Pujol, Ignacio Gomez Centurion, Veronica Castro |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Population 030204 cardiovascular system & hematology Toxicology Pharmacovigilance 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Drug Interactions Pharmacology (medical) Prospective Studies 030212 general & internal medicine education Intensive care medicine Kidney transplantation media_common Pharmacology Polypharmacy education.field_of_study business.industry Proton Pump Inhibitors Middle Aged Drug interaction medicine.disease Kidney Transplantation Tacrolimus Sirolimus Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business Immunosuppressive Agents medicine.drug |
| Zdroj: | Current Drug Safety. 11:156-163 |
| ISSN: | 1574-8863 |
| DOI: | 10.2174/157488631102160429003742 |
| Popis: | Aim: Renal transplant patients are frequently subject to polypharmacy and drug-drug interactions. However, no previous study has systematically assessed the risk of drug interactions and Adverse Drug Reactions (ADRs) in this population. Methods: A total of 138 consecutive adult kidney transplant recipients admitted to our hospital between August 2010 and February 2012 were prospectively and systematically assessed by our pharmacovigilance team, within 24 hours of admission, to identify potential drug-drug interactions and probable ADRs. Results: As a consequence of the high number of medications per patient (7.8±0.2 drugs), a considerable number of drugdrug interactions were observed in this population, with an average of 5.6±0.4 drug interactions per patient. Moreover, a significant percentage of admissions (~10%) of kidney transplant patients were related to probable ADRs. Almost all these patients had at least one drug interaction that could have potentially contributed to the probable ADR. Of note, clinically significant (i.e. severe) drug interactions were more frequent among patients with ADRs (29% vs. 15%, p |
| Databáze: | OpenAIRE |
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