Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
| Autor: | Murat Yücel, Pedro Vieira da Silva Magalhães, G. Paul Amminger, Seetal Dodd, Francesco Giorlando, Olivia M Dean, Ana Cristina Andreazza, Michael Maes, Michael Berk, Patrick D. McGorry, Flávio Kapczinski, Clarissa Severino Gama, Brian Dean, Gin S Malhi |
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| Rok vydání: | 2011 |
| Předmět: |
Bipolar Disorder
Cognitive Neuroscience Inflammation Mitochondrion Proinflammatory cytokine Behavioral Neuroscience Neurotrophic factors medicine Animals Humans Nerve Growth Factors Bipolar disorder Neurotransmitter Agents biology Neurogenesis medicine.disease Oxidative Stress Neuroprotective Agents Neuropsychology and Physiological Psychology Disease Progression biology.protein Cytokines medicine.symptom Psychology Neuroscience Neurocognitive Neurotrophin |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 35:804-817 |
| ISSN: | 0149-7634 |
| Popis: | There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted from an initial focus on monoamines, subsequently including evidence of changes in intracellular second messenger systems and more recently to, incorporating changes in inflammatory cytokines, corticosteroids, neurotrophins, mitochondrial energy generation, oxidative stress and neurogenesis into a more comprehensive model capable of explaining some of the clinical features of BD. These features include progressive shortening of the inter-episode interval with each recurrence, occurring in consort with reduced probability of treatment response as the illness progresses. To this end, emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations. This understanding facilitates identification of rational therapeutic targets, and the development of novel treatment classes. Additionally, these pathways provide a cogent explanation for the efficacy of seemingly diverse therapies used in BD, that appear to share common effects on oxidative, inflammatory and neurotrophic pathways. |
| Databáze: | OpenAIRE |
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