Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies
| Autor: | Margaret I. Urban, Mark Schiffman, S. Bayo, Joakim Dillner, M. Vessey, P. A. Rolón, Ilvars Silins, J. Green, T. M.N. Farley, James V. Lacey, G. Reeves, Jack Cuzick, Giorgia Randi, A Berrington de González, Didier Colin, B. Crossley, Saibua Chichareon, L A Brinton, C. Velarde, Nubia Muñoz, Freddy Sitas, E. Negri, R. Barnabas, J. R. Daling, N. Chaouki, Ruth K. Peters, Doudja Hammouda, Lara Stein, Inger T. Gram, Karen Canfell, S. Sweetland, C. La Vecchia, Xavier Castellsagué, Carlos Ferreira dos Santos, Roberta M. Ray, Margaret M. Madeleine, P. Appleby, D. Bull, O. Meirik, Franz X. Bosch, Susanne K. Kjaer, Valerie Beral, José Eluf-Neto, R Herrero, Manuel Álvarez, Nathalie Ylitalo, R. Painter, S de Sanjosé, Thangarajan Rajkumar, Allan Hildesheim, Corazon A. Ngelangel, M. C. Pike, David C. G. Skegg, David B. Thomas, Victor Moreno, M Plummer, Silvia Franceschi, O. Galdos, P. Hannaford, Giske Ursin, Julian Peto |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Risk
Adult Cancer Research medicine.medical_specialty HPV Adolescent International Cooperation Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Cervical Cancer World Health Organization Risk Assessment Cohort Studies Pregnancy Risk Factors Epidemiology medicine Confidence Intervals cancer Humans Women Developing Countries Cervical cancer Gynecology Obstetrics business.industry Carcinoma in situ Incidence Reproduction Carcinoma cervical Age Factors medicine.disease Uterine Cervical Dysplasia Confidence interval Sexual intercourse Parity Oncology Relative risk Case-Control Studies Cancer Control Survivorship and Outcomes Research - Surveillance Female pregnancy business Cancer Type - Cervical Cancer |
| Zdroj: | International journal of cancer. Journal international du cancer. 119(5) |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | The International Collaboration of Epidemiological Studies of Cervical Cancer has combined individual data on 11,161 women with invasive carcinoma, 5,402 women with cervical intraepithelial neoplasia (CIN)3/carcinoma in situ and 33,542 women without cervical carcinoma from 25 epidemiological studies. Relative risks (RRs) and 95% confidence intervals (CIs) of cervical carcinoma in relation to number of full-term pregnancies, and age at first full-term pregnancy, were calculated conditioning by study, age, lifetime number of sexual partners and age at first sexual intercourse. Number of full-term pregnancies was associated with a risk of invasive cervical carcinoma. After controlling for age at first full-term pregnancy, the RR for invasive cervical carcinoma among parous women was 1.76 (95% CI: 1.53-2.02) for > or => or =7 full-term pregnancies compared with 1-2. For CIN3/carcinoma in situ, no significant trend was found with increasing number of births after controlling for age at first full-term pregnancy among parous women. Early age at first full-term pregnancy was also associated with risk of both invasive cervical carcinoma and CIN3/carcinoma in situ. After controlling for number of full-term pregnancies, the RR for first full-term pregnancy at age or => or =25 years was 1.77 (95% CI: 1.42-2.23) for invasive cervical carcinoma, and 1.78 (95% CI: 1.26-2.51) for CIN3/carcinoma in situ. Results were similar in analyses restricted to high-risk human papilloma virus (HPV)-positive cases and controls. No relationship was found between cervical HPV positivity and number of full-term pregnancies, or age at first full-term pregnancy among controls. Differences in reproductive habits may have contributed to differences in cervical cancer incidence between developed and developing countries. |
| Databáze: | OpenAIRE |
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