Self-Assembly of Metallo-Nucleoside Hydrogels for Injectable Materials That Promote Wound Closure
| Autor: | Huizhen Yu, Zhilei Ge, Qian Li, Hao Pei, Qian Tang, Tong Zhu, Li Li, Jeffery T. Davis, Taylor N. Plank |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Staphylococcus aureus
Magnetic Resonance Spectroscopy Materials science Dimer Supramolecular chemistry 02 engineering and technology Microscopy Atomic Force 010402 general chemistry 01 natural sciences Mice chemistry.chemical_compound Tissue engineering Escherichia coli Animals General Materials Science chemistry.chemical_classification Wound Healing Tissue Engineering Hydrogels Nucleosides Cytidine Polymer 021001 nanoscience & nanotechnology Anti-Bacterial Agents 0104 chemical sciences chemistry Chemical engineering Pseudomonas aeruginosa Self-healing hydrogels Self-assembly Burns 0210 nano-technology Nucleoside |
| Zdroj: | ACS Applied Materials & Interfaces. 11:19743-19750 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Injectable hydrogels are increasingly being used as scaffolds for in situ tissue engineering and wound healing. Most of these injectable hydrogels are made from polymers, and there are fewer examples of such soft materials made via self-assembly of low-molecular weight gelators. We report the room-temperature synthesis of a functional hydrogel formed by mixing cytidine (C) with 0.5 equiv each of B(OH)3 and AgNO3. The structural basis for this supramolecular hydrogel (C-B-C·Ag+) involves orthogonal formation of cytidine borate diesters (C-B-C) and Ag+-stabilized C-C base pairs, namely, the C·Ag+·C dimer. The C-B-C·Ag+ hydrogels, which can have high water content (at least 99.6%), are stable (no degradation after 1 year in the light), stimuli-responsive, and self-supporting, with elastic moduli of up to 104 Pa. Incorporation of Ag+ ions into the gel matrix endows the C-B-C·Ag+ hydrogel with significant antibacterial capability. Importantly, the rapid switching between the sol and gel states for this supramolecular hydrogel, as a response to shear stress, enables 3D printing of a flexible medical patch made from the C-B-C·Ag+ hydrogel. The C-B-C·Ag+ hydrogel was used to promote the closure of burn wounds in a mouse model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|