Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1
| Autor: | Jing Chen, Charlie Ma, Li-Li Chen, Ru-Bo Cao, Pindong Li, Hong Ma, Jing Yao, Wen-Jie Zhang, Jianli Hu, Kun-Yu Yang, Tian-Tian Cheng, Gang Wu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Esophageal Neoplasms LASP1 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Cell Line Tumor microRNA medicine Humans PVT1 Adaptor Proteins Signal Transducing Cell Proliferation Gene knockdown long non-coding RNA business.industry Cancer RNA LIM Domain Proteins miR-203 medicine.disease Prognosis Long non-coding RNA Up-Regulation esophageal squamous cell carcinoma Gene Expression Regulation Neoplastic Cytoskeletal Proteins MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Disease Progression Female RNA Long Noncoding business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Pin-Dong Li 1, 2, * , Jian-Li Hu 1, * , Charlie Ma 2 , Hong Ma 1 , Jing Yao 1 , Li-Li Chen 2 , Jing Chen 1 , Tian-Tian Cheng 3 , Kun-Yu Yang 1 , Gang Wu 1 , Wen-Jie Zhang 4 and Ru-Bo Cao 1 1 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2 Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA 3 Cancer Center of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510059, China 4 Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China * These authors have contributed equally to this work Correspondence to: Ru-Bo Cao, email: caorubao@126.com Keywords: long non-coding RNA, PVT1, LASP1, miR-203, esophageal squamous cell carcinoma Received: November 01, 2016 Accepted: January 16, 2017 Published: March 03, 2017 ABSTRACT Long non-coding RNAs are a group of non-coding RNAs longer than 200 nucleotides and possess diverse functions and exhibit exquisite cell-specific and developmental dynamic expression patterns. The role of the long non-coding RNA PVT1 in esophageal squamous cell carcinoma remains unsolved. Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth in vitro and in vivo . Further studies revealed that silence of PVT1 lead to up-regulation of miR-203, and vice versa. Moreover, LASP1 was found to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown. Our results suggest that PVT1 promote ESCC progression via functioning as a molecular sponge for miR-203 and LASP1 and provide the first evidence of dysregulated PVT1/miR-203/LASP1 axis in ESCC. |
| Databáze: | OpenAIRE |
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