Cellular immune responses in human neurocysticercosis
| Autor: | Mahajan Rc, Gurjeet Bhatti, Sukhbir Kaur, Nirmal Kumar Ganguly, Nancy Malla, I. M. S. Sawhney, Jasvir Singh Grewal |
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| Rok vydání: | 2000 |
| Předmět: |
CD4-Positive T-Lymphocytes
Interleukin 2 medicine.medical_treatment Lymphocyte CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Neurocysticercosis Immunophenotyping Interferon-gamma Immune system Antigen medicine Humans Interleukin 4 Immunity Cellular General Veterinary Receptors IgG HLA-DR Antigens General Medicine Th1 Cells CD56 Antigen Lymphocyte Subsets Infectious Diseases Cytokine medicine.anatomical_structure Antigens Helminth Insect Science CD4 Antigens Immunology Interleukin-2 Parasitology Interleukin-4 CD8 medicine.drug |
| Zdroj: | Parasitology Research. 86:500-503 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s004360050701 |
| Popis: | Studies on the role of cell-mediated immune responses in human neurocysticercosis (NCC) are lacking. Various cell-mediated immune responses such as lymphocyte subpopulation, lymphocyte transformation to cysticercus antigens and cytokine profile were carried out in NCC patients. Lymphocyte transformation assays using larval antigens showed significantly higher (3)H-thymidine uptake. Immunophenotyping analysis showed an insignificant increase in B cells and a decrease in total T cells. However, there was a significant decrease (P0.05) in CD8+ T cells whereas there was no change in other cells like CD4+, HLA-DR+ and CD16+/CD56+. Cytokine profile revealed significantly higher (P0.01) production of Th1 cytokines (gamma-IFN and IL-2) using cysticercal antigens as stimulants for peripheral blood mononuclear cells, while there was no difference in IL-4 levels between NCC patients and healthy controls. The cytokine profile indicated the involvement of Th-1-like responses in NCC patients. |
| Databáze: | OpenAIRE |
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