Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium
| Autor: | Sven Moesgaard, Jens Jørgen Sloth, Erik Højkjær Larsen, Kim Overvad, Lars C. Steenberg, Knut Flytlie, Susanne Bügel |
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| Přispěvatelé: | Pharma Nord, Vejle, Denmark |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Veterinary medicine
Selenium yeast Stable isotope Humans Pharmacokinetics Absorption Excretion chemistry.chemical_element Absorption (skin) Urine chemistry.chemical_compound Animal science stable isotope Medicine humans Feces Nutrition and Dietetics business.industry Public Health Environmental and Occupational Health selenium yeast Yeast chemistry pharmacokinetics absorption excretion Original Article business Selenium Food Science Former LIFE faculty |
| Zdroj: | Bügel, S G, Larsen, E H, Sloth, J J, Flytlie, K, Overvad, K, Steenberg, L C & Moesgaard, S 2008, ' Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium ', Food & Nutrition Research, vol. 52 . https://doi.org/10.3402/fnr.v52i0.1642 Bügel, S, Larsen, E H, Sloth, J J, Flytlie, K, Overvad, K, Steenberg, L C & Moesgaard, S 2008, ' Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium ', Food & Nutrition Research, vol. 52 . https://doi.org/10.3402/fnr.v52i0.1642 Food & Nutrition Research; Vol 52 (2008) Food & Nutrition Research |
| ISSN: | 1654-661X 1654-6628 |
| DOI: | 10.3402/fnr.v52i0.1642 |
| Popis: | Objective: The purpose of this study was to evaluate the pharmacokinetics of a single dose of Se from yeast given to humans with a habitual long-term daily intake at a supra-nutritional level. Research Methods & Procedures: Twelve healthy males with a daily supplemental intake of 300 m g Se as selenised yeast over 10 weeks were supplemented with a single dose of 327 m g as stable 77 Se incorporated into selenised yeast manufactured by the same standardised process (SelenoPrecise ©, Pharma Nord, Denmark). Results: Absorption of Se from 77 Se-enriched yeast was 89 ± 4 % and the retention was 74 ± 6 %. The 77 Se excretion from the single-dose was 47 ± 15 m g in urine and 37 ± 13 m g in faeces. The maximum, enriched 77 Se concentration in plasma was 9.8 ± 1.5 m g/l and the time to maximum was 9.2 hours. The plasma halftime of 77 Se was longer with increasing time; 1.7 days for the initial phase (½ - 2 days), 3.0 days for the middle phase (2 - 3 days) and 11.1 days for the later phase (3 - 14 days). Conclusion: The Se from the standardised Se-enriched yeast was well absorbed and retained in the body. (Published online: 12 February, 2008) Citation: Food & Nutrition Research 2008. DOI: 10.3402/fnr.v52i0.1642 |
| Databáze: | OpenAIRE |
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