Process variations between Swiss units treating neonates with hypoxic-ischemic encephalopathy and their effect on short-term outcome
| Autor: | Beate Grass, Martin Stocker, Barbara Brotschi, Verena Rathke, Sven Schulzke, Cornelia Hagmann, Juliane Schneider, Mark Adams, Giancarlo Natalucci |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty media_common.quotation_subject Encephalopathy Logistic regression Article Hypoxic Ischemic Encephalopathy 03 medical and health sciences 0302 clinical medicine Hypothermia Induced Pregnancy 030225 pediatrics Retrospective analysis Humans Medicine 030212 general & internal medicine Retrospective Studies media_common Selection bias business.industry Infant Newborn Temperature Outcome measures Obstetrics and Gynecology Translational research Hypothermia medicine.disease Health services Indirect standardization Outcomes research Hypoxia-Ischemia Brain Pediatrics Perinatology and Child Health Female medicine.symptom business Switzerland |
| Zdroj: | Journal of Perinatology |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-021-01156-w |
| Popis: | Objective To compare therapeutic hypothermia (TH) treatment of term and near-term neonates with hypoxic-ischemic encephalopathy (HIE) between neonatal units. Study design Population-based, retrospective analysis of TH initiation and maintenance, and of diagnostic imaging. The comparison between units was based on crude data analysis, indirect standardization, and adjusted logistic regression. Results TH was provided to 570 neonates with HIE between 2011 and 2018 in 10 Swiss units. We excluded 121 off-protocol cooled neonates to avoid selection bias. Of the remaining 449 neonates, the outcome was favorable to international benchmarks, but there were large unit-to-unit variations in baseline perinatal data and TH management. A total of 5% neonates did not reach target temperature within 7 h (3–10% between units), and 29% experienced over- or undercooling (0–38%). Conclusion Although the neonates had favorable short-term outcomes, areas for improvement remain for Swiss units in both process and outcome measures. |
| Databáze: | OpenAIRE |
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