Symptomatic endometriosis developing several years after menopause in the absence of increased circulating estrogen concentrations: a systematic review and seven case reports
| Autor: | Mario Malzoni, P.A. Ribeiro, Leila Adamyan, Helizabet Salomao Abdalla Ayroza Ribeiro, Fernanda de Almeida Asencio, Philippe R. Koninckx, Victor Gomel, Dan C. Martin, Anastasia Ussia |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
DEEP ENDOMETRIOSIS
medicine.medical_specialty medicine.drug_class PATHOGENESIS lcsh:Surgery Reproductive medicine Endometriosis Physiology lcsh:Gynecology and obstetrics DISEASE Exogenous estrogen 03 medical and health sciences 0302 clinical medicine Surgical oncology medicine Genetics MANAGEMENT MIMICKING lcsh:RG1-991 BOWEL OBSTRUCTION 030219 obstetrics & reproductive medicine Science & Technology medicine.diagnostic_test business.industry Obstetrics and Gynecology Interventional radiology lcsh:RD1-811 medicine.disease Pathophysiology Menopause Postmenopausal endometriosis INFILTRATION Estrogen 030220 oncology & carcinogenesis Surgery Pathophysiology of endometriosis Epigenetics business SIGMOID ENDOMETRIOSIS Life Sciences & Biomedicine HORMONAL-THERAPY |
| Zdroj: | Gynecological Surgery, Vol 16, Iss 1, Pp 1-11 (2019) |
| Popis: | BackgroundTo review women with symptomatic and clinically progressive endometriosis after menopause in the absence of estrogen intake or excessive systemic endogenous production.DesignSeven case reports and a systematic review of the literature from 1995 till February 2018.ResultsOnly 7 case reports from the authors and 29 cases from the literature described women with either cystic ovarian or deep endometriosis. Severity, symptoms, and localization are highly variable. No case report describes symptomatic superficial typical lesions. In 22 of 36 women (61%), symptoms started more than 10 years after menopause.ConclusionsSymptomatic and clinically progressive endometriosis after menopause in the absence of increased systemic estrogen concentrations or exogenous estrogen intake starts more than 10 years after menopause in the majority of women. This observation suggests that a genetic and/or epigenetic incident caused estrogen-independent progression, increased sensitivity to estrogens or increased local production of estrogens. This observation is important for understanding the pathophysiology of endometriosis, for the management of postmenopausal endometriosis, and for individualization of medical therapy of endometriosis since estrogen-independent endometriosis growth probably also occurs before menopause. |
| Databáze: | OpenAIRE |
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