Multifunctional use of casein as release system and blocking layer for implant coatings
| Autor: | Meier, Nils, Menzel, Henning |
|---|---|
| Přispěvatelé: | SPhERe - 3rd International Symposium on Pharmaceutical Engineering Research, 25. - 27. September 2019 |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ddc:615
ddc:615.19 615.19 Article casein-micelles tissue engineering ddc:66 ddc:660 ddc:6 ddc:61 Veröffentlichung der TU Braunschweig casein-micelles -- surface functionalization -- blocking layers -- controlled release -- tissue engineering controlled release surface functionalization blocking layers |
| Popis: | In situ tissue engineering requires to functionalize the surfaces of implants, to achieve better biocompatibility or to release pharmaceuticals. Often a burst release of such pharmaceuticals takes place and the surface functionality is gone rapidly. Casein-micelles (M-Cas) offer unique release capabilities for hydrophobic and hydrophilic substances. In this work, M-Cas were reconstructed and used as release system for curcumin as a model drug. Modified electrospun polycaprolactone (PCL)-fiber mats were coated with chitosan / tripolyphosphate nanoparticles (CS/TPP-NP) and functionalized with the reconstructed M-Cas. [1] CS/TPP-NPs and Na-caseinate (Cas) were used as blocking layer to slow down the release of curcumin loaded micelles. The layers were investigated by surface zeta-potential (ZP). The release of the curcumin from surfaces was possible and the blocking layers had a significant influence on the kinetics. SPhERe Proceedings: 4th International Symposium on Pharmaceutical Engineering Research |
| Databáze: | OpenAIRE |
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