Presence of hepatitis B virus core promoter mutations pre-seroconversion predict persistent viral replication after HBeAg loss
| Autor: | R. Bridget Ferns, Richard Gilson, Nikolai V. Naoumov, Richard S. Tedder |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Hepatitis B virus Adolescent Genotype Virus Replication medicine.disease_cause Virus Hepatitis B Chronic Orthohepadnavirus Virology medicine Humans Hepatitis B e Antigens Hepatitis B Antibodies Seroconversion Promoter Regions Genetic biology business.industry virus diseases Viral Load medicine.disease biology.organism_classification Hepatitis B Core Antigens digestive system diseases Phenotype Infectious Diseases HBeAg Hepadnaviridae Hepatocellular carcinoma DNA Viral Mutation Immunology Female business |
| Zdroj: | Journal of Clinical Virology. 39:199-204 |
| ISSN: | 1386-6532 |
| DOI: | 10.1016/j.jcv.2007.04.008 |
| Popis: | Background: In patients with chronic hepatitis B virus (HBV) infection DNA levels do not always fall after anti-hepatitis B e (anti-HBe) seroconversion. Objectives: To follow longitudinally through HB e antigen (HBeAg) loss HBV DNA levels and core promoter/precore sequences in a cohort of 21 chronic HBV carriers. Study design: Treatment-na¨ ove HBeAg seropositive HBV carriers were monitored through HBeAg loss for between 2 and 22 years (mean 9.3). Core promoter/precore sequences, genotypes, HBV DNA levels and HBe status were determined. Results: Patients were grouped into those in whom serum/plasma HBV DNA remained high after HBeAg loss (group 1, n = 11; HBV DNA > 5 log10 IU/ml) and those in whom HBV DNA declined (group 2, n = 10). Re-appearance of HBeAg was seen in seven group 1 patients. Pre-seroconversion mutations in the core promoter region including A1762T and/or G1764A were detected more frequently in group 1 (P = 0.031). Overall sequence changes at sites other than 1762/1764 were more common post-seroconversion in group 1 than group 2 patients (P = 0.037). Conclusions: The presence of core promoter mutations prior to HBeAg loss identified those patients in whom HBV DNA persisted at high levels and was associated with temporary re-emergence of serum HBeAg. These patients may benefit from early anti-viral treatment. © 2007 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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