Biobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals
| Autor: | Milene M. Hornink, Alice Uva Lopes, Leandro H. Andrade |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Formamide
010405 organic chemistry Chemistry business.industry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Renewable energy chemistry.chemical_compound Molecular targets Reactivity (chemistry) Itaconic acid Formamides business FOTOQUÍMICA |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0040-1707318 |
| Popis: | Spiroimides exhibit a wide range of biological activities, such as anticonvulsant, antiarrhythmic, and antihyperglycemic activities. Herein, a novel synthetic application of renewable chemicals, itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro[dihydroquinolin-2-one-succinimides] and spiro[indolin-2-one-glutarimides], in excellent overall yields (up to 98%). |
| Databáze: | OpenAIRE |
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