GISSI trial: Early results and late follow-up
| Autor: | Claudio De Vita, Antonio Lotto, Aldo Selvini, Rovelli F, Gissi Investigators, Gianni Tognoni, Giorgio A. Feruglio |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
business.industry Streptokinase Incidence (epidemiology) Infarction medicine.disease law.invention Surgery Clinical trial Randomized controlled trial Early results law Internal medicine Statistical significance medicine Myocardial infarction Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. 10:33B-39B |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/s0735-1097(87)80426-6 |
| Popis: | In the GISSI trial, 11,712 patients with acute myocardial infarction were randomized to receive either standard care or standard care with 1.5 million units streptokinase intravenously. A highly significant reduction in mortality during hospitalization in streptokinase-treated patients was observed. The mortality at 1 year was determined in 98.3% of the patients who had been originally randomized; the 1 year mortality of patients discharged alive was similar in those patients treated with streptokinase and those who were not; that is, the beneficial effects of streptokinase treatment on survival that were observed in the hospital phase of the study persisted unchanged and with comparable statistical significance for 1 year. However, a higher incidence of reinfarction occurred in the treated versus the control groups both during the hospital phase and at the 6 month follow-up. Streptokinase treatment had no detectable effect in patients with a history of previous infarction. |
| Databáze: | OpenAIRE |
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