Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
| Autor: | Jianliang Lu, Simranjit Kaur, Serena Stopponi, David L. McKinzie, Min Song, Johannes Tauscher, Jacqueline Hersh, Anh D. Lê, Marsida Kallupi, Simone Braconi, Chafiq Hamdouchi, Erik James Hembre, Daniel W. Hommer, Donald R. Gehlert, Nazzareno Cannella, Roberto Ciccocioppo, Maurizio Massi, Giordano de Guglielmo, Stephen P. Hunt, Philip Arthur Hipskind, Jody Gilman, Andrey E. Ryabinin, David T. George, Andrea Cippitelli, Daina Economidou, Jeffrey W. Cramer, Markus Heilig, Annika Thorsell, Michelle Morin |
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| Rok vydání: | 2009 |
| Předmět: |
Health (social science)
Corticotropin-Releasing Hormone Alcohol abuse Neurotransmission Anxiety Toxicology Biochemistry Receptors Corticotropin-Releasing Hormone Article Behavioral Neuroscience Corticotropin-releasing hormone Neurokinin-1 Receptor Antagonists medicine Animals Humans Neuropeptide Y Opioid peptide Urocortins Urocortin General Medicine medicine.disease Neuropeptide Y receptor Nociceptin receptor Alcoholism Neurology Opioid Peptides medicine.symptom Psychology Neuroscience Stress Psychological |
| Zdroj: | Alcohol (Fayetteville, N.Y.). 43(7) |
| ISSN: | 1873-6823 |
| Popis: | This article summarizes the proceedings of a symposium held at the conference on “Alcoholism and Stress: A Framework for Future Treatment Strategies” in Volterra, Italy, May 6–9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol related behaviours in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin releasing factor (CRH) receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory indicating a role of the urocortin 1 (Ucn) receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropetide Y (NPY) receptor system in the modulation of behaviours associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 (NK1) antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism. |
| Databáze: | OpenAIRE |
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