Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube
| Autor: | Aysu Uygur, Clifford J. Tabin, Mervenaz Koska, Tyler R. Huycke, John J. Young, James Briscoe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neural Tube animal structures Body Patterning Neural tube patterning Embryonic Development Nerve Tissue Proteins Context (language use) Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences GLI3 medicine Animals Hedgehog Proteins Sonic hedgehog Molecular Biology Zebra finch Embryonic Induction Neurons Neural tube Gene Expression Regulation Developmental Cell Biology Anatomy Cell biology 030104 developmental biology medicine.anatomical_structure Spinal Cord Vertebrates embryonic structures Trans-Activators biology.protein Chickens Transcription Factors Signal Transduction Morphogen Developmental Biology |
| Zdroj: | Developmental cell |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2016.03.024 |
| Popis: | SUMMARY Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly understood. We have examined this phenomenon in the context of the patterning of the ventral neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two species that differ in size during the time of neural tube patterning. We find that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3. This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself. |
| Databáze: | OpenAIRE |
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