MicroRNAs in IgA nephropathy
| Autor: | Jingge Gao, Yaling Zhai, Huanping An, Wenhui Zhang, Xingchen Yao, Yazhuo Chen, Zhanzheng Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Diagnostic methods
diagnosis Review Critical Care and Intensive Care Medicine Bioinformatics urologic and male genital diseases Severity of Illness Index Nephropathy microRNA medicine Humans medicine.diagnostic_test Mechanism (biology) business.industry pathogenesis Glomerulonephritis Glomerulonephritis IGA MicroRNA General Medicine IgA nephropathy medicine.disease Prognosis Diseases of the genitourinary system. Urology MicroRNAs Nephrology State-of-the-Art Review Nephritis Interstitial RC870-923 Renal biopsy business Biomarkers |
| Zdroj: | Renal Failure article-version (VoR) Version of Record Renal Failure, Vol 43, Iss 1, Pp 1298-1310 (2021) |
| ISSN: | 1525-6049 |
| Popis: | IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. It is considered that the pathogenesis of IgAN involves the ‘multiple hit theory’ and the immune-inflammatory mechanism; however, these theories have certain limitations. The gold standard for diagnosing IgAN is still renal biopsy. Although renal biopsy is accurate, it is traumatic and is associated with some risks and limitations, so there is a need for non-invasive diagnostic methods. According to recent studies, microRNAs (miRNAs) play important roles in the occurrence and development of IgAN; thus, they provide the possibility of the noninvasive diagnosis of IgAN and also have some value in predicting prognosis. This review summarizes the current research status of miRNAs in the occurrence, development, diagnosis, and prognosis of IgAN. We also highlight some interesting and challenging points that require further study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |