The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway
| Autor: | Leonardo Castellanos, Silvana Maria Zucolotto, Eloir Paulo Schenkel, Freddy A. Ramos, Andressa Córneo Gazola, Thereza Christina Monteiro de Lima, Geison M. Costa |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.drug_class Passifloraceae Flavonoid 01 natural sciences Passiflora Mice Oral administration medicine Animals Hypnotics and Sedatives GABAergic Neurons Medicinal plants GABA Modulators gamma-Aminobutyric Acid Pharmacology chemistry.chemical_classification Flavonoids Diazepam Traditional medicine biology Dose-Response Relationship Drug 010405 organic chemistry Plant Extracts food and beverages General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Metabolic pathway Mechanism of action chemistry Sedative medicine.symptom Signal Transduction |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 100 |
| ISSN: | 1950-6007 |
| Popis: | The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2''-O-xyloside, vitexin-2''-O-glucoside, orientin-2''-O-xyloside and orientin-2''-O-glucoside. Vitexin-2"-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice. |
| Databáze: | OpenAIRE |
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