Advances in chemical proteomic evaluation of lipid kinases – DAG kinases as a case study
| Autor: | Timothy B. Ware, Ku-Lung Hsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Proteomics
Diacylglycerol Kinase Chemistry Kinase Phosphotransferases Lipid kinase activity Activity-based proteomics Chemical biology Computational biology Biochemistry Lipids Article Mass Spectrometry Analytical Chemistry Lipidomics lipids (amino acids peptides and proteins) Kinome Diacylglycerol kinase |
| Zdroj: | Curr Opin Chem Biol |
| Popis: | Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biology of lipid kinases with a focus on those members that phosphorylate diacylglycerols. We further discuss future implications of how these mass spectrometry-based approaches can be adapted for studies of additional lipid kinase members with the aim of bridging the gap between protein and lipid kinase-focused investigations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|