Drug Use during Pregnancy and its Consequences: A Nested Case Control Study on Severe Maternal Morbidity
| Autor: | Carla Silveira, Renato T. Souza, Dulce M. Zanardi, Carina R. Angelini, Mary Angela Parpinelli, Rodolfo C. Pacagnella, José Guilherme Cecatti, Carla Betina Andreucci, Cynara Maria Pereira |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Substance-Related Disorders Denver Developmental Screening Test illicit drugs Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Pregnancy Severity of illness medicine Humans Childbirth 030212 general & internal medicine Retrospective Studies drug use child development Psychotropic Drugs 030219 obstetrics & reproductive medicine high risk pregnancy Obstetrics business.industry Pregnancy Outcome Infant Obstetrics and Gynecology Retrospective cohort study Gynecology and obstetrics medicine.disease Pregnancy Complications Substance abuse Neurodevelopmental Disorders Case-Control Studies Child Preschool Nested case-control study Cohort RG1-991 Female pregnancy business |
| Zdroj: | Revista Brasileira de Ginecologia e Obstetrícia v.40 n.9 2018 Revista brasileira de ginecologia e obstetrícia Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO Revista Brasileira de Ginecologia e Obstetrícia, Vol 40, Iss 9, Pp 518-526 (2018) |
| Popis: | To assess the relationship between the use of psychoactive substances during pregnancy and the occurrence of severe maternal morbidity (SMM), perinatal outcomes and repercussions on the neuropsychomotor development of exposed children. A case-control study nested within a cohort of severe maternal morbidity (COMMAG) was performed. Women with SMM were considered cases. Controls were those with low-risk pregnancy, without SMM and admitted during the same time period as the cases. Cohort data were collected retrospectively in hospital records for childbirth. A face-to-face interview was also performed with 638 women (323 without SMM and 315 with SMM) and their children of the index pregnancy between 6 months and 5 years after childbirth. During the interview, substance abuse during pregnancy was assessed by a modified question from the Alcohol, Smoking and Substance Involvement Screening Test 2.0 (ASSIST) and the neuropsychomotor development in the children was assessed by the Denver Developmental Screening Test, 2 The prevalence of licit or illicit drug use during pregnancy was ∼ 17%. Among drug users, 63.9% used alcohol, 58.3% used tobacco, 9.2% used cocaine/crack and 4.6% used marijuana. There was no association between drug use during pregnancy and SMM, although tobacco use during pregnancy was associated with bleeding, presence of near-miss clinical criteria (NMCC) and alteration in infant development; alcohol use was associated with neonatal asphyxia; and cocaine/crack use was associated with the occurrence of some clinical complications during pregnancy. The use of psychoactive substances during pregnancy is frequent and associated with worse maternal, perinatal and child development outcomes. Avaliar a relação entre o uso de substâncias psicoativas na gestação e a ocorrência de morbidade materna grave (MMG), resultados perinatais e repercussões no desenvolvimento neuropsicomotor das crianças expostas. MéTODOS: Estudo de caso-controle a partir de uma coorte de morbidade materna grave (COMMAG). Mulheres com MMG foram consideradas casos. Controles foram mulheres com gestação de baixo risco, admitidas no mesmo período que os casos. Os dados da coorte foram coletados retrospectivamente em prontuários de internação para o parto e entrevistas presenciais conduzidas com 638 mulheres e seus filhos da gestação-índice, entre 6 meses e 5 anos após o parto. Na entrevista, o uso de substâncias na gestação foi avaliado com uma pergunta modificada introduzida no questionário para triagem do uso de álcool, tabaco e outras substâncias 2.0 (ASSIST, na sigla em inglês) e o desenvolvimento neuropsicomotor das crianças foi avaliado pelo teste de triagem do desenvolvimento Denver II. A prevalência do uso de drogas lícitas ou ilícitas na gestação foi de cerca de 17%. Das usuárias, 63,9% usaram álcool, 58,3% usaram tabaco, 9,2% usaram cocaína/crack e 4,6% usaram maconha. Não houve associação entre o uso de drogas na gestação e MMG. Contudo, o uso de tabaco foi associado a hemorragia, presença de critérios clínicos de |
| Databáze: | OpenAIRE |
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