HIV vaccine development and clinical trials
| Autor: | Marybeth McCauley, Mary Glenn Fowler, Rodney Hoff, James McNamara |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
HIV Infections Disease Acquired immunodeficiency syndrome (AIDS) Pregnancy Risk Factors Pandemic Humans Medicine Pregnancy Complications Infectious HIV vaccine AIDS Vaccines Clinical Trials as Topic business.industry Transmission (medicine) Vaccination Infant Newborn virus diseases General Medicine medicine.disease Virology Infectious Disease Transmission Vertical Clinical trial Treatment Outcome Immunization Pediatrics Perinatology and Child Health Female Viral disease business |
| Zdroj: | Acta Paediatrica. 83:73-77 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1994.tb13340.x |
| Popis: | The magnitude of HIV pandemic has made the development of HIV vaccines an urgent biomedical research priority. Although the biologic problems in designing a vaccine for a chronic viral infection like HIV are formidable, there has been encouraging progress. More than a dozen first generation prophylactic HIV vaccine candidates have completed phase I human trials that have established the safety and immunogenicity of these products in adults. A phase II trial of two HIV subunit envelope vaccines in adults at high risk of HIV infection is underway in the United States, and preparations for phase III efficacy trials have begun. Preliminary studies are under way to evaluate the potential application of active and passive immunization for preventing vertical transmission of HIV. Because of the higher rate of HIV transmission and a more abbreviated time course to disease, it may be more efficient to evaluate the efficacy of HIV vaccines in HIV infected pregnant women and their offspring than in adults who are exposed sexually to HIV. |
| Databáze: | OpenAIRE |
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