Herquline B, a New Platelet Aggregation Inhibitor Produced by Penicillium herquei Fg-372
| Autor: | Satoshi Omura, Yumi Enomoto, Kazuro Shiomi, Rokuro Masuma, Keiichi Tomosawa, Tomoya Kawakubo, Masahiko Hayashi, Yuzuru Iwai |
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| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Bacteria Platelet Aggregation Stereochemistry Chemical structure Penicillium Biological activity Penicillium herquei Biology Pyrrolidine Piperazine chemistry.chemical_compound Alkaloids chemistry Drug Discovery Animals Platelet aggregation inhibitor Platelet Rabbits IC50 Platelet Aggregation Inhibitors |
| Zdroj: | The Journal of Antibiotics. 49:50-53 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.49.50 |
| Popis: | A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 microM, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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