Oral bacteria – The missing link to ambiguous findings of exhaled nitrogen oxides in cystic fibrosis
| Autor: | Lennart Nordvall, Kjell Alving, Marie Johannesson, Elisabeth Näs, Wilhelm Zetterquist, Pia Kalm-Stephens, H Marteus |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Saliva Pathology Adolescent Nitrite Mouthwashes Breath condensate Nitrate Cystic fibrosis Gastroenterology Nitric oxide chemistry.chemical_compound Young Adult Internal medicine Forced Expiratory Volume medicine Humans Exhaled breath condensate Child Nitrites Nitrates Bacteria business.industry Chlorhexidine medicine.disease Mucus respiratory tract diseases chemistry Breath Tests Exhalation Exhaled nitric oxide Female business |
| Zdroj: | Respiratory Medicine. 103(2):187-193 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2008.09.009 |
| Popis: | SummaryBackgroundNitrite in exhaled breath condensate (EBC) has been shown to be elevated in cystic fibrosis (CF), while exhaled nitric oxide (FENO) is paradoxically low. This has been argued to reflect increased metabolism of NO while its diffusion is obstructed by mucus. However, we wanted to study the possible influence of salivary nitrite and bacterial nitrate reduction on these parameters in CF patients by the intervention of an anti-bacterial mouthwash.MethodsEBC and saliva were collected from 15 CF patients (10–43 years) and 15 controls (9–44 years) before and 5min after a 30s chlorhexidine mouthwash, in parallel with measurements of FENO. Nitrite and nitrate concentrations were measured fluorometrically.ResultsEBC nitrite, but not nitrate, was significantly higher in the CF patients (median 3.6 vs 1.3μM in controls, p |
| Databáze: | OpenAIRE |
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