Chitosan dosage regimen to trap fecal oil excretion after peroral lipase inhibitor administration in mice
| Autor: | Hesson Chung, Cheol Won Yun, Yura Jang, Young Tae Je |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Evaluation Preclinical Administration Oral macromolecular substances Biochemistry Bile Acids and Salts Chitosan Excretion Feces Lactones 03 medical and health sciences chemistry.chemical_compound Structural Biology In vivo medicine Animals Enzyme Inhibitors Molecular Biology Orlistat Mice Inbred BALB C 030109 nutrition & dietetics Chromatography technology industry and agriculture General Medicine Hydrogen-Ion Concentration equipment and supplies In vitro Thin-layer chromatography Soybean Oil Molecular Weight carbohydrates (lipids) chemistry Oil droplet Lipase inhibitors Female Anti-Obesity Agents Hair medicine.drug |
| Zdroj: | International Journal of Biological Macromolecules. 94:484-491 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2016.10.003 |
| Popis: | This study was designed to investigate the oil entrapment and systemic oil absorption-reducing activities of chitosan. High-molecular-weight chitosan formed gel aggregates with oil and bile salts in vitro. The oil/chitosan ratio and the molecular weight of chitosan were optimized for the in vivo study, and a molecular weight >100,000 was effective in reducing the oil contamination of mouse fur. The oil/chitosan weight ratio required for effective oil entrapment was less than 13 and 5 in the in vitro and in vivo experiments, respectively. Chitosan administration was most effective during meals, and high-molecular-weight chitosan could trap and facilitate the reduction of systemic absorption of oil droplets separated by orlistat. The activity of the lipase inhibitor was not altered by chitosan as evidenced by thin layer chromatography, and orlistat was not absorbed systemically by the co-administration of chitosan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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