Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration
| Autor: | Véronique Marcel, Christophe Pertuy, Patrick Masson, Didier Fournier, Laurent Gagnoux Palacios |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Kinetics Biochemistry Catalysis Substrate Specificity chemistry.chemical_compound Animals Caenorhabditis elegans Molecular Biology Butyrylcholinesterase chemistry.chemical_classification biology Substrate (chemistry) Cell Biology biology.organism_classification Acetylcholinesterase Enzyme Activation Enzyme Drosophila melanogaster chemistry Cholinesterase Inhibitors Baculoviridae Research Article |
| Zdroj: | Scopus-Elsevier ResearcherID |
| Popis: | In vertebrates there are two cholinesterases, with differences in catalytic behaviour with respect to substrate concentration: butyrylcholinesterase displays an increased activity at low substrate concentrations, whereas acetylcholinesterase displays inhibition by excess substrate. In two invertebrates, Drosophila melanogaster and Caenorhabditis elegans, we found cholinesterases that showed both kinetic complexities: substrate activation at low substrate concentrations followed by inhibition at higher concentrations. These triphasic kinetics can be explained by the presence of two enzymes with different kinetic behaviours or more probably by the existence of a single enzyme regulated by the substrate concentration. |
| Databáze: | OpenAIRE |
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