Putrescine bisamides from Aglaia gigantea
| Autor: | Anh Tuan Duong, Wenhan Lin, Walter Frank, Victor Wray, RuAngelie Edrada, Tu Ngoc Duong, Peter Proksch, Rainer Ebel |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.drug_class
Stereochemistry Molecular Conformation Pharmaceutical Science Carboxamide Crystallography X-Ray Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Putrescine Organic chemistry Derivatization Nuclear Magnetic Resonance Biomolecular Pharmacology Plants Medicinal biology Aglaia Molecular Structure Chemistry Organic Chemistry Absolute configuration Gigantea biology.organism_classification Plant Leaves Complementary and alternative medicine Phytochemical Vietnam Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural products. 70(10) |
| ISSN: | 0163-3864 |
| Popis: | Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide ( 1), as well as two new natural products, gigantamide A ( 2) and grandiamide D ( 3). In this study, the structure of dasyclamide ( 1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A ( 2) and grandiamide D ( 3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D ( 3) was determined via Mosher ester derivatization. |
| Databáze: | OpenAIRE |
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