MAPK cascade gene family in Camellia sinensis: In-silico identification, expression profiles and regulatory network analysis

Autor:	Ashutosh Pandey, Anurag P. Srivastava, G. Meher Unnati, Archita Chatterjee, Tamalika Kar, Trisha Biswas, Neelam Mishra, Ruchika Rajput, Abhirup Paul, Srijita Basak
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0106 biological sciences 0301 basic medicine MAPK/ERK pathway lcsh:QH426-470 MAP Kinase Signaling System In silico lcsh:Biotechnology Computational biology MAPK cascade Mitogen-activated protein kinase kinase 01 natural sciences Camellia sinensis 03 medical and health sciences Gene Expression Regulation Plant Expression profile Arabidopsis lcsh:TP248.13-248.65 Genetics Gene family Arabidopsis thaliana Gene Regulatory Networks Gene Plant Proteins biology Functional interaction network biology.organism_classification lcsh:Genetics 030104 developmental biology In-silico Mitogen-Activated Protein Kinases 010606 plant biology & botany Biotechnology Research Article
Zdroj:	BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020) BMC Genomics
ISSN:	1471-2164
Popis:	Background Mitogen Activated Protein Kinase (MAPK) cascade is a fundamental pathway in organisms for signal transduction. Though it is well characterized in various plants, there is no systematic study of this cascade in tea. Result In this study, 5 genes of Mitogen Activated Protein Kinase Kinase (MKK) and 16 genes of Mitogen Activated Protein Kinase (MPK) in Camellia sinensis were found through a genome-wide search taking Arabidopsis thaliana as the reference genome. Also, phylogenetic relationships along with structural analysis which includes gene structure, location as well as protein conserved motifs and domains, were systematically examined and further, predictions were validated by the results. The plant species taken for comparative study clearly displayed segmental duplication, which was a significant candidate for MAPK cascade expansion. Also, functional interaction was carried out in C. sinensis based on the orthologous genes in Arabidopsis. The expression profiles linked to various stress treatments revealed wide involvement of MAPK and MAPKK genes from Tea in response to various abiotic factors. In addition, the expression of these genes was analysed in various tissues. Conclusion This study provides the targets for further comprehensive identification, functional study, and also contributed for a better understanding of the MAPK cascade regulatory network in C. sinensis.
Databáze:	OpenAIRE
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