Effects of dietary fatty-acid supplementation on fatty-acid composition and deformability of young and old erythrocytes
| Autor: | David E. Mills, Heather J. Dixon, William R. Galey |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Biophysics Phospholipid Biology Biochemistry Safflower oil chemistry.chemical_compound Fish Oils Dietary Fats Unsaturated Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Dietary Fatty Acid Humans Dietary supplementation Phospholipids Safflower Oil Cell Size Fatty Acids Water Erythrocyte Aging Cell Biology Fish oil Red blood cell Endocrinology medicine.anatomical_structure chemistry Fatty Acids Unsaturated Female Composition (visual arts) Fatty acid composition |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1149:313-318 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/0005-2736(93)90216-m |
| Popis: | The effects of cell age on erythrocyte phospholipid fatty-acid composition and deformability were examined in 20 healthy adults (11 male, 9 female) prior to and following 12 weeks of dietary supplementation with 3.5 g/day of safflower oil (high in n - 6 fatty acids) or fish oil (high in n - 3 fatty acids). In the absence of dietary supplementation, old erythrocytes demonstrated an increase in filtration time (P < 0.001), an increase in membrane phospholipid total n - 6 fatty acids (P < 0.01), and a decrease in total n - 3/total n - 6 ratio (P < 0.01) compared to young erythrocytes. Both safflower and fish oil supplementation attenuated age-related differences in membrane phospholipid total n - 6 and total n - 3 fatty acids. Fish oil supplementation also increased the proportion of n - 3 fatty acids (P < 0.01) and then - 3n - 6ratio (P < 0.05) in the phospholipids of both young and old erythrocytes, and eliminated age-related differences in erythrocyte filtration time by reducing the relative filtration time of the old erythrocytes. |
| Databáze: | OpenAIRE |
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