Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning
| Autor: | André Heinen, Jan Fraessdorf, Iris Hanschmann, Nina C. Weber, Ragnar Huhn, Markus W. Hollmann, Benedikt Preckel |
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| Přispěvatelé: | Amsterdam Cardiovascular Sciences, Anesthesiology, Amsterdam institute for Infection and Immunity |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Ischemia lcsh:Medicine Dynorphin Internal medicine medicine Animals Rats Wistar lcsh:Science Ischemic Preconditioning Opioid peptide Endogenous opioid Cardioprotection Multidisciplinary business.industry lcsh:R medicine.disease Rats Endocrinology Opioid Peptides Opioid Coronary occlusion Ischemic preconditioning lcsh:Q lipids (amino acids peptides and proteins) business Research Article medicine.drug |
| Zdroj: | PLoS ONE, 10(7). Public Library of Science PLoS ONE PLoS ONE, Vol 10, Iss 7, p e0134283 (2015) |
| DOI: | 10.1371/journal.pone.0134283 |
| Popis: | Background Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown. We investigated whether 1) OR are involved in the trigger and/or mediation phase of LPC and 2) a time course effect on the expression of different opioid receptors and their endogenous ligands exists. Methods Male Wistar rats were randomly allocated to four groups (each group n = 8). Awake animals were ischemic preconditioned by a 5 minutes coronary occlusion. 24 hours later, anesthetized animals underwent 25 minutes coronary occlusion followed by 2 hours of reperfusion. The role of OR was investigated by treatment with intraperitoneal naloxone (Nal) 10 minutes prior to LPC (Nal-LPC; trigger phase) or 10 min prior to sustained ischemia (LPC-Nal; mediation phase). Results LPC reduced infarct size from 61±10% in controls to 25±9% (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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