Basaloid Squamous Cell Carcinoma of the Larynx: A National Cancer Database Analysis
| Autor: | Mejd Jumaily, Ronald J. Walker, Gregory M. Ward, Farhoud Faraji, Donald Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Larynx Pathology medicine.medical_specialty Adolescent Databases Factual Database analysis Cell Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans 030223 otorhinolaryngology Basaloid Squamous Cell Carcinoma Head and neck Laryngeal Neoplasms Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Cancer Histology Middle Aged medicine.disease Combined Modality Therapy United States Otorhinolaryngologic Surgical Procedures Survival Rate medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Surgery business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 160:847-854 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599818816299 |
| Popis: | Basaloid squamous cell histology is a rare variant that accounts for about 2% of all head and neck squamous cell laryngeal carcinomas. The purpose of this study was to examine overall survival rates of patients according to treatment, stage, and laryngeal subsite.Retrospective analysis.National Cancer Database (NCDB).The NCDB was queried for patients with basaloid squamous cell carcinoma (BSCC) who were treated from 2004 to 2014. Five-year overall survival rates were determined by the Kaplan-Meier method. Univariate and multivariate analysis was used to identify factors correlated with 5-year overall survival.The NCDB identified 440 patients meeting inclusion criteria. Median follow-up time was 31.2 months. On univariate analysis, the treatment modalities assessed (surgery alone, surgery with radiotherapy, surgery with chemoradiotherapy, radiotherapy, chemoradiotherapy) did not differ in their survival benefit. On multivariate analysis, only chemoradiotherapy (hazard ratio, 0.587; 95% CI, 0.37-0.93; P = .022) was associated with improved survival. All treatment modalities performed similarly between stage I and II tumors ( P = .340) and stage III and IV tumors ( P = .154).This study represents the largest laryngeal BSCC series to date. We found that chemoradiotherapy was associated with improved 5-year overall survival of laryngeal BSCC on multivariate analysis. |
| Databáze: | OpenAIRE |
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