Effects of anacetrapib on plasma lipids in specific patient subgroups in the DEFINE (Determining the Efficacy and Tolerability of CETP INhibition with AnacEtrapib) trial

Autor: Eliot A. Brinton, Uma Kher, Sukrut Shah, Christopher P. Cannon, Michael Davidson, Antonio M. Gotto, Tanya B. Ashraf, Christine McCrary Sisk, Hayes Dansky, Yale Mitchel, Philip Barter, M. Gerstman, L. Howes, K. Kostner, P. Nestel, D. Sullivan, H. Brath, J. Patsch, B. Paulweber, H. Toplak, C.M. Constance, E. Howlett, D. Mymin, L. Pliamm, K.K. Saunders, J.-C. Tardif, R. Tytus, P. Aschner, S. Keinänen-Klukaanniemi, T. Strandberg, M.-R. Taskinen, G. Luc, D. Richter, J.L. Schlienger, Y. Zaïr, K.-F. Appel, M. Baar, C. Luley, U. Overhoff, T. Pomykaj, T. Schaefer, S.T. Lau, K.L.F. Lee, K. Tan, B. Tomlinson, M.W. Tsang, K. Badacsonyi, Á. Kalina, N. Kanakaridisz, L. Márk, É. Péterfai, L. Regos, I. Reiber, J. Takács, A. Vértes, A. Elis, D. Gavish, D. Harats, O. Hussein, T. Hayek, E. Leitersdorf, A.K. Bin Abdul Ghapar, K.H. Chee, S.B. Ismail, K.H. Ling, G.R.L. Ramanathan, K.H. Sim, R. Alvarado, M. Benavides, G.E. Cardona, G. Gonzalez, J. Verdejo, D.C.G. Basart, B.P.M. Imholz, J.J.C. Jonker, P.R. Nierop, J.L. Posma, Th.B. Twickler, E. Barrington-Ward, R. Cutfield, D.H. Friedlander, R.S. Scott, H. Istad, G. Langslet, G.K. Skjelvan, S.J. Campodónico Hoyos, R. Coloma Araniya, A. Gallegos C., C.A. Pino Morales, L. Watanabe, G.P. Arutyunov, A.B. Blokhin, M.G. Bubnova, S.Y. Marcevich, C. Álvarez Sánchez, L.A. Álvarez-Sala Walther, B. Gil Extremera, F. Perez Jimenez, L. de Teresa Parreño, C.-P. Anderberg, U. Hedin, A. Hellberg, P. Höök, T. Kjellström, P. Nilsson, A.G. Olsson, U. Rosenqvist, K. Tolagen, T. Wolff, A. Baskin, H.E. Bays, R.I. Bernstein, N. Bittar, E.A. Brinton, L.H.K. Chee, R.A. Cottiero, R.D. D'Agostino, M.H. Davidson, P.S. Denker, R.K. Garcia, R.K. Hippert, T. Isakov, S.R. Kaster, B. Kerzner, E.J. Klein, M.J. Koren, M.E. Kutner, D. Liljenquist, D.G. Lorch, R. Lorraine, B.C. Lubin, N.M. Lunde, T.J. Majchrzak, J.M. McKenney, S. Mukherjee, D.D. Muse, M.S. Otruba, J.E. Pappas, K. Patrick, S.J. Powell, E. Riffer, L.D. Rink, J.L. Rohlf, J.B. Rosen, P.D. Rosenbilt, E.M. Roth, C.J. Rubenstein, J. Rubino, L.A. Rudolph, A. Schneider, W.G. Short, J.C. Silverfield, D.P. Suresh, G.A. Tarshis, P.D. Toth, R.W. Townsend, T.O. Wahl
Přispěvatelé: DEFINE Investigators
Rok vydání: 2013
Předmět:
Zdroj: Journal of clinical lipidology
ISSN: 1933-2874
Popis: Background In the Determining the Efficacy and Tolerability of cholesteryl ester transfer protein (CETP) INhibition with AnacEtrapib (DEFINE) trial, anacetrapib added to statin produced robust low-density lipoprotein cholesterol (LDL-C)-lowering and high-density lipoprotein cholesterol (HDL-C)-raising vs placebo in patients with coronary heart disease (CHD). Predictors of the degree of LDL-C and HDL-C responses to anacetrapib, however, are poorly understood. Objective Lipid effects of anacetrapib in patient subgroups within the DEFINE trial (clinicaltrials.gov: NCT00685776) are reported. Methods The percent of placebo-corrected changes from baseline for LDL-C (estimated by Friedewald calculation [Fc-LDL-C]) and HDL-C after 24 weeks of anacetrapib 100 mg/day were compared among patients by age, gender, race, diabetes status, type of concomitant statin with or without other lipid therapies, and baseline HDL-C, Fc-LDL-C, and triglyceride (TG) levels. Results Percent decreases in Fc-LDL-C and increases in HDL-C with anacetrapib were similar (magnitude of difference generally
Databáze: OpenAIRE
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