Physiological and autonomic stress responses after prolonged sleep restriction and subsequent recovery sleep in healthy young men

Autor: Wessel M. A. van Leeuwen, Tarja Porkka-Heiskanen, Mikael Sallinen, Harri Lindholm, Mikko Härmä, Christer Hublin, Ari Hirvonen, Jussi Virkkala
Přispěvatelé: Tarja Stenberg / Principal Investigator, Medicum, Department of Physiology, University of Helsinki
Rok vydání: 2017
Předmět:
syke
medicine.medical_specialty
Neurology
Physiology
BLOOD-PRESSURE
030204 cardiovascular system & hematology
SYMPATHOVAGAL BALANCE
3124 Neurology and psychiatry
uni (lepotila)
Cortisol
stress
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Internal medicine
autonominen hermosto
medicine
Autonomic nervous system
Heart rate variability
Circadian rhythm
Applied Psychology
Sleep restriction
HEART-RATE-VARIABILITY
business.industry
CIRCADIAN-RHYTHM
3112 Neurosciences
Tillämpad psykologi
Sleep in non-human animals
3. Good health
INSUFFICIENT SLEEP
Neuropsychology and Physiological Psychology
Blood pressure
Endocrinology
NEUROPEPTIDE-Y
CARDIOVASCULAR-DISEASE
HPA-axis
ONE NIGHT
IMMUNE-SYSTEM
Original Article
DEPRESSED-PATIENTS
hearts
Prolonged sleep
business
030217 neurology & neurosurgery
Zdroj: Sleep and Biological Rhythms
ISSN: 1479-8425
1446-9235
DOI: 10.1007/s41105-017-0122-x
Popis: Purpose Sleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to prolonged sleep restriction and subsequent recovery sleep in healthy young men. Methods After two baseline (BL) nights of 8 h time in bed (TIB), TIB was restricted to 4 h per night for five nights (sleep restriction, SR, n = 15), followed by three recovery nights (REC) of 8 h TIB, representing a busy workweek and a recovery weekend. The control group (n = 8) had 8 h TIB throughout the experiment. A variety of autonomic cardiovascular parameters, together with salivary neuropeptide Y (NPY) and cortisol levels, were assessed. Results In the control group, none of the parameters changed. In the experimental group, heart rate increased from 60 +/- 1.8 beats per minute (bpm) at BL, to 63 +/- 1.1 bpm after SR and further to 65 +/- 1.8 bpm after REC. In addition, whole day low-frequency to-high frequency (LF/HF) power ratio of heart rate variability increased from 4.6 +/- 0.4 at BL to 6.0 +/- 0.6 after SR. Other parameters, including salivary NPY and cortisol levels, remained unaffected. Conclusions Increased heart rate and LF/HF power ratio are early signs of an increased sympathetic activity after prolonged sleep restriction. To reliably interpret the clinical significance of these early signs of physiological stress, a follow-up study would be needed to evaluate if the stress responses escalate and lead to more unfavourable reactions, such as elevated blood pressure and a subsequent elevated risk for cardiovascular health problems.
Databáze: OpenAIRE
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