Nephrogenic systemic fibrosis following exposure to gadolinium-containing contrast agent
| Autor: | T Watter, K Technau, E Schwertfeger, S Clorius, Peter Gerke, K.-G. Fischer, Gerd Walz |
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| Rok vydání: | 2007 |
| Předmět: |
Nephrology
Nephrogenic Fibrosing Dermopathy Gadolinium DTPA Male medicine.medical_specialty Pathology Systemic disease Contrast Media Kidney Magnetic resonance angiography Fibrosis Internal medicine medicine Humans Aged Skin Scleroderma Systemic medicine.diagnostic_test business.industry General Medicine medicine.disease Connective tissue disease Nephrogenic systemic fibrosis Kidney Failure Chronic business Magnetic Resonance Angiography Kidney disease |
| Zdroj: | Clinical nephrology. 68(4) |
| ISSN: | 0301-0430 |
| Popis: | Nephrogenic systemic fibrosis (NSF) is a disease recently described in patients with kidney failure. It is characterized by scleroderma-like thickening of the skin, subcutaneous edema and ensuing joint contractures leading to profound disability. Furthermore, involvement of internal organs has been described. Whereas the pathogenesis is not known to date, recent reports have linked NSF to high doses of gadolinium-containing contrast agents given at magnetic resonance angiography (MRA). We describe a patient with severe NSF. The patient had received erythropoietin and had undergone vascular interventions which are suspected risk factors for this disease. Notably, the disease developed shortly after the application of gadolinium at an MRA, giving support to the recently published hypothesis that gadolinium-containing contrast agents are among the causative factors. We provide a short overview and hope to raise overall awareness towards this entity and the use of MRA contrast agents in renal patients. |
| Databáze: | OpenAIRE |
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