Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer
| Autor: | Lauren S. Jammallo, Marybeth Singer, Cynthia L. Miller, Michelle C. Specht, Melissa N. Skolny, Jean O’Toole, Nora Horick, Alphonse G. Taghian |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Risk Cancer Research medicine.medical_specialty Breast Neoplasms Article Body Mass Index Breast cancer hemic and lymphatic diseases Internal medicine Humans Medicine Lymphedema Postoperative Period Risk factor Aged Aged 80 and over Gynecology business.industry Proportional hazards model Incidence (epidemiology) Body Weight Weight change Weight Fluctuation Middle Aged medicine.disease body regions Oncology Preoperative Period Female business Body mass index Follow-Up Studies |
| Zdroj: | Breast Cancer Research and Treatment. 142:59-67 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-013-2715-7 |
| Popis: | Identifying risk factors for lymphedema in patients treated for breast cancer has become increasingly important, given the current lack of standardization surrounding diagnosis and treatment. Reports on the association of body mass index (BMI) and weight change with lymphedema risk are conflicting. We sought to examine the impact of pre-operative BMI and post-treatment weight change on the incidence of lymphedema. From 2005 to 2011, 787 newly diagnosed breast cancer patients underwent prospective arm volume measurements with a Perometer pre- and post-operatively. BMI was calculated from same-day weight and height measurements. Lymphedema was defined as a relative volume change (RVC) of ≥ 10 %. Univariate and multivariate Cox proportional hazards models were used to evaluate the association between lymphedema risk and pre-operative BMI, weight change, and other demographic and treatment factors. By multivariate analysis, a pre-operative BMI ≥ 30 was significantly associated with an increased risk of lymphedema compared to a pre-operative BMI |
| Databáze: | OpenAIRE |
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