Human telomerase gene amplification and high-risk human papillomavirus infection in women with cervical intra-epithelial neoplasia
| Autor: | Mario Poljak, Andreja Zagorac, Darja Arko, Tatjana Kodrič, Alenka Erjavec-Škerget, Iztok Takač, Nadja Kokalj-Vokac |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Pathology medicine.medical_specialty viruses Uterine Cervical Neoplasms urologic and male genital diseases Biochemistry Young Adult Risk Factors Internal medicine Gene duplication medicine Humans In patient Prospective Studies Human papillomavirus neoplasms Cervix Papillomaviridae Telomerase Early Detection of Cancer In Situ Hybridization Fluorescence Aged Cervical cancer Human telomerase business.industry Biochemistry (medical) Significant difference Papillomavirus Infections Gene Amplification virus diseases Cell Biology General Medicine Middle Aged medicine.disease Uterine Cervical Dysplasia female genital diseases and pregnancy complications medicine.anatomical_structure ROC Curve Female business Oncovirus |
| Zdroj: | The Journal of international medical research. 37(5) |
| ISSN: | 0300-0605 |
| Popis: | This study was designed to investigate whether a correlation exists between amplification of the human telomerase gene (human telomerase RNA component [ TERC]) and high-risk human papillomavirus (HR-HPV) infection in 101 women with cervical intra-epithelial neoplasia (CIN). Eight patients (7.9%) had CIN 1, 24 (23.8%) had CIN 2 and 69 (68.3%) had CIN 3. TERC was amplified in 31.7% of all CIN patients. The difference in frequency of TERC amplification between patients with low-grade CIN (CIN 1) and those with high-grade CIN (CIN 2 and CIN 3) was not significant. HR-HPV infection was detected in 88.1% of all CIN cases and was significantly more frequent in patients with CIN 2 and CIN 3 than in patients with CIN 1. There was no significant difference in the frequency of HR-HPV infection between groups of patients with and without TERC amplification. In conclusion, this study found no correlation between TERC amplification and HR-HPV infection in patients with CIN. |
| Databáze: | OpenAIRE |
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