Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry
| Autor: | Yibing Du, Ping Wei, C Y Tu, Qi Zhang, Guoguang Chen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Metabolic Clearance Rate
Administration Oral Urine Pharmacognosy Tandem mass spectrometry Mass spectrometry High-performance liquid chromatography Mass Spectrometry Rats Sprague-Dawley Feces Pharmacokinetics Animals Bile Pharmacology (medical) Pharmacology Chromatography Chemistry Saponins Triterpenes Rats Bioavailability Area Under Curve Injections Intravenous Chromatography Liquid Drugs Chinese Herbal |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 30:269-273 |
| ISSN: | 2107-0180 0378-7966 |
| DOI: | 10.1007/bf03190631 |
| Popis: | Pharmacokinetics of Astragaloside IV (AGS-IV) in rats was studied by high performance liquid chromatography coupled with tandem mass spectrometry. The concentration in plasma was determined after i.v. administration of 1, 2, 4 mg/kg and p.o. administration of 20 mg/kg of AGS-IV. The AUC were linearly correlated to doses. Recoveries of AGS-IV in bile, urine and feces were also analyzed following i.v. dose of 2 mg/kg. Cumulative recovery of AGS-IV in bile reached 30.8% in 24h. Cumulative recovery of AGS-IV in urine and feces was 52.14%, which indicates that about 50% of AGS-IV was metabolized in vivo. The bioavailability of AGS-IV after p.o. administration was found to be 3.66%. These findings provide useful information for the research and development of AGS-IV and other potential agents. |
| Databáze: | OpenAIRE |
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