Antibacterial and In Vivo Studies of a Green, One-Pot Preparation of Copper/Zinc Oxide Nanoparticle-Coated Bandages
| Autor: | Paride Mantecca, Ilana Perelshtein, Archana R. Deokar, Aharon Gedanken, Nina Perkas, Yeshayahu Nitzan, Melissa Saibene |
|---|---|
| Přispěvatelé: | Deokar, A, Perelshtein, I, Saibene, M, Perkas, N, Mantecca, P, Nitzan, Y, Gedanken, A |
| Rok vydání: | 2021 |
| Předmět: |
Oxide
chemistry.chemical_element Nanoparticle Filtration and Separation TP1-1185 02 engineering and technology Zinc 010402 general chemistry 01 natural sciences Article Sonochemistry chemistry.chemical_compound Chemical engineering In vivo Chemical Engineering (miscellaneous) Ultrasound irradiation CuO/ZnO NP Chemical technology Process Chemistry and Technology Water Ignition problem 021001 nanoscience & nanotechnology Copper 0104 chemical sciences Antibacterial Solvent chemistry Nanotoxicology CuO/ZnO NPs TP155-156 0210 nano-technology Antibacterial activity Nuclear chemistry |
| Zdroj: | Membranes Volume 11 Issue 7 Membranes, Vol 11, Iss 462, p 462 (2021) |
| ISSN: | 2077-0375 |
| DOI: | 10.3390/membranes11070462 |
| Popis: | Simultaneous water and ethanol-based synthesis and coating of copper and zinc oxide (CuO/ZnO) nanoparticles (NPs) on bandages was carried out by ultrasound irradiation. High resolution-transmission electron microscopy demonstrated the effects of the solvent on the particle size and shape of metal oxide NPs. An antibacterial activity study of metal-oxide-coated bandages was carried out against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). CuO NP-coated bandages made from both water and ethanol demonstrated complete killing of S. aureus and E. coli bacteria within 30 min., whereas ZnO NP-coated bandages demonstrated five-log reductions in viability for both kinds of bacteria after 60 min of interaction. Further, the antibacterial mechanism of CuO/ZnO NP-coated bandages is proposed here based on electron spin resonance studies. Nanotoxicology investigations were conducted via in vivo examinations of the effect of the metal-oxide bandages on frog embryos (teratogenesis assay—Xenopus). The results show that water-based coatings resulted in lesser impacts on embryo development than the ethanol-based ones. These bandages should therefore be considered safer than the ethanol-based ones. The comparison between the toxicity of the metal oxide NPs prepared in water and ethanol is of great importance, because water will replace ethanol for bulk scale synthesis of metal oxide NPs in commercial companies to avoid further ignition problems. The novelty and importance of this manuscript is avoiding the ethanol in the typical water:ethanol mixture as the solvent for the preparation of metal oxide NPs. Ethanol is ignitable, and commercial companies are trying the evade its use. This is especially important these days, as the face mask produced by sonochemistry (SONOMASK) is being sold all over the world by SONOVIA, and it is coated with ZnO. |
| Databáze: | OpenAIRE |
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